Kaelyn Sumigray Alumna page
Background & Contact Information
Currently: Assistant Professor of Genetics, Yale University
Postdoctoral Fellow, Peifer lab, (2012 – 2013) Postdoctoral Fellow, Lechler Lab, Duke University (2014-2019(
Education: Ph.D., Cell Biology, Duke University, Durham, NC 2011
B.S., Biology, Union College, Schenectady, NY 2005
Fellowships & Awards: NIH NRSA Postdoctoral Fellowship; Lineberger Cancer Center Postdoctoral Fellowship
Email: kaelyn.sumigray@duke.edu
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Research Information
During Drosophila embryogenesis, the establishment of epithelial polarity and the formation of cell-cell junctions are closely linked. I am interested in understanding the interdependence of polarity proteins and junctional proteins during embryo formation. In particular, I aim to understand the role of the adherens junction-associated protein Canoe during embryogenesis, with a focus on its interactions with Rap1 GTPase.
Publications
Bonello, T.T., Perez-Vale, K.Z., Sumigray, K.D., and Peifer, M. (2018) Rap1 acts via multiple mechanisms to position Canoe/Afadin and adherens junctions and mediate apical-basal polarity establishment. .
Rogers, E.M., Spracklen, A.J., Bilancia, C.G., Sumigray, K.D., Allred, S.C., Nowotarski, S.N., Schaefer, K. N., Ritchie, B.J., and Peifer, M. (2016). Abelson kinase acts as a robust, multifunctional scaffold in regulating embryonic morphogenesis. Molecular Biology of the Cell 27, 2613-31.
Choi, W., Harris, N. J., Sumigray, K.D., and Peifer, M. (2013). Rap1 and Canoe/afadin are essential for establishment of apical-basal polarity in the Drosophila embryo. Molecular Biology of the Cell, 24, 945-963.
Sumigray, KD, Foote H and Lechler T. (2012) Non-centrosomal microtubules and Type II Myosins Potentiate Epidermal Cell Adhesion and Barrier Formation. J Cell Biol. 199:513-525..
Sumigray, K.D. and Peifer, M. (2012) Cell shape by coercion: Par1 and aPKC put the squeeze on junctions. Developmental Cell 22-907-908.
Sumigray, KD and Lechler T. (2012) Desmoplakin Controls Microvilli Length but not Cell Adhesion or Keratin Organization in the Intestinal Epithelium. Mol Biol Cell. 23: 792-9.
Sumigray, KD and Lechler T. (2011). Control of Cortical Microtubule Organization and Desmosome Stability by Centrosomal Proteins. Bioarchitecture. 1: 1-4.
Sumigray, KD, Chen H, and Lechler T. (2011) Lis1 is Essential for Cortical Microtubule Organization and Desmosome Function in the Epidermis. J Cell Biol. 194: 631-42.
Sumigray, KD and Lechler, T. (2010) Dissecting cell adhesion crosstalk with micropatterns. Proc Natl Acad Sci USA. 107: 13199.
