References
2024
Gurley, N.J., and Peifer, M. (2024). Moonwalking Molecular Machines: Unraveling the Choreography of Myosin Filament Assembly. Journal of Cell Biology, in press.
Jensen CC, and Peifer, M. (2024) Too old for hide-and-seek; cell maturation reveals hidden apical junctional organization. PNAS. in press.
McParland, E.D.*, Butcher, T.A.*, Gurley, N.J., Johnson, R.I., Slep, K.C., and Peifer, M. (2024) Canoe’s Dilute domain is not essential for linking cell junctions to the cytoskeleton but supports morphogenesis robustness. Journal of Cell Science, in press. *=co-first authors.
Dunn, A.R., and Peifer, M. (2024). Bill Weis (1959-2023): Pioneering structural biologist and biochemist who revolutionized our understanding of cell adhesion and Wnt signaling. Journal of Cell Biology, in press.
2023
Gurley, N.J., Szymanski, R.A., Dowen, R.H., Butcher, T.A., Ishiyama, N. and Peifer, M. (2023). Exploring the evolution and function of Canoe’s intrinsically disordered region in linking cell-cell junctions to the cytoskeleton during embryonic morphogenesis. PLoS One 18: e0289224. [PUBMED]
Schmidt, A., Finegan, T., Häring, M., Kong, D., Fletcher, A.G., Alam, Z., Grosshans, J., Wolf, F., and Peifer, M. (2023). Polychaetoid/ZO-1 strengthens cell junctions under tension while localizing differently than core adherens junction proteins. Molecular Biology of the Cell 34: ar81. [PUBMED]
Perez-Vale, K.Z.*, Yow, K,D.*, Gurley, N. J., Greene, M., and Peifer, M. (2023) Rap1 regulates apical contractility to allow embryonic morphogenesis without tissue disruption and acts in part via Canoe-independent mechanisms. Molecular Biology of the Cell 34:ar7. doi: 10.1091/mbc.E22-05-0176. [PUBMED]
2022
Peifer, M. (2022). To condense or not to condense: Wnt regulation by centrosome-nucleated biomolecular condensates. Proceedings of the National Academy of Sciences-USA 119:e2213905119. [PUBMED]
Bischoff, M.C., and Peifer, M. (2022) Cell biology: Keeping the epithelium together when your neighbor divides. Current Biology 32(20):R1025-R1027. [PUBMED]
Fernandez-Gonzalez, R., and Peifer , M. (2022) Powering morphogenesis: multiscale challenges at the interface of cell adhesion and the cytoskeleton. Molecular Biology of the Cell 33, https://doi.org/10.1091/mbc.E21-09-0452. [PUBMED].
Yu-Kemp, H.-C., Szymanski, R.A., Cortes, D.B., Gadda, N.C., Lillich, M.I., Maddox, A.S., and Peifer, M. (2021) Micron-scale supramolecular myosin arrays help mediate cytoskeletal assembly at mature adherens junctions. Journal of Cell Biology, 221:e202103074. [PUBMED]
2021
Perez-Vale, KZ., Yow, K,D., Johnson, R, I,. Byrnes, A.E., Finegan, T.M., Slep, K.C., and Peifer, M. (2021) Multivalent interactions make adherens junction-cytoskeletal linkage robust during morphogenesis. Journal of Cell Biology 220: e202104087. [PUBMED]
Peifer, M. (2021). Looking back on a life of unacknowledged privilege and a call to action. Molecular Biology of the Cell 32:1081-1085. doi: 10.1091/mbc.E21-01-0024. [PDF] [PUBMED]
Rogers, E.M., Allred, S.C., and Peifer, M. (2021). Abelson kinase’s intrinsically disordered region plays essential roles in protein function and protein stability. Cell Communication and Signaling 19:27. doi: 10.1186/s12964-020-00703-w. [PUBMED]
2020
Perez-Vale, K.Z, and Peifer, M. (2020). Orchestrating morphogenesis: building the body plan by cell shape changes and movements. Development 147, dev191049. [PUBMED]
Schmidt, A., and Peifer, M. (2020). Scribble and Dlg organize a protection racket to ensure apical-basal polarity. Proc. Nat. Acad Sci. USA 117:13188-13190. [PUBMED]
Schaefer, K.N., Pronobis, M., Williams, C.E., Zhang, S., Bauer, L., Goldfarb, D., Yan, F., Major, M.B., Peifer, M. (2020). Wnt Regulation: Exploring Axin-Disheveled interactions and defining mechanisms by which the SCF E3 ubiquitin ligase is recruited to the destruction complex. Molecular Biology of the Cell 31:992-1014 [PUBMED]
Yu-Kemp, H.-C., and Peifer, M. (2020). Good fences make good neighbors: Crumbs regulates Rho-kinase dynamics to assemble a tissue boundary. Developmental Cell 52, 255-256 [AuthorLink] [PUBMED]
Peifer, M. (2020). “The Eighth Day of Creation”: looking back across 40 years to the birth of molecular biology and the roots of modern cell biology. Molecular Biology of the Cell 31, 81-86. [PUBMED] [MBoC] [AuthorVersion-full text]
2019
Bonello, T.T., Choi, W., and Peifer, M. (2019). Scribble and Discs-large direct initial assembly and positioning of adherens junctions during establishment of apical-basal polarity. Development . [PUBMED]
Spracklen, A.J., Thornton-Kolbe, E.M., Bonner, A,N., Florea, A., Compton, P.J., Fernandez-Gonzalez, R., and Peifer, M. (2019). The Crk adapter protein is essential for Drosophila embryogenesis where it regulates multiple actin-dependent morphogenic events. Molecular Biology of the Cell 30, 2399-2421. [PUBMED]
Manning, L.A., Perez-Vale, K.Z., Schaefer, K.N., Sewell, M.T., Peifer, M. (2019). The Drosophila Afadin and ZO-1 homologs Canoe and Polychaetoid act in parallel to maintain epithelial integrity when challenged by adherens junction remodeling. Molecular Biology of the Cell 30, 1938-1960. [PUBMED]
Poulton, J.S. McKay, D. J., and Peifer M. (2019). Centrosome loss triggers a transcriptional program to counter apoptosis-induced oxidative stress. Genetics 212,187-211. [PUBMED]
Schaefer, K.N., and Peifer M. (2019). Wnt/Beta-catenin signaling regulation and a role for biomolecular condensates. Developmental Cell 48:429-44. [PUBMED]
Bonello, T.T. and Peifer, M. (2019). Scribble: A master scaffold in polarity, adhesion, synaptogenesis and proliferation. Journal of Cell Biology, in press. [PUBMED] [PreprintLink]
Manning, L.A., and Peifer, M.(2019). Getting into shape: tissue tension drives oriented cell divisions during organogenesis. EMBO Journal e101246 DOI 10.15252/embj.2018101246. [PUBMED]
2018
Perez-Vale, K.Z., and Peifer, M. (2018). Modulating Apical-Basal Polarity by Building and Deconstructing a Yurt. Journal of Cell Biology 217, 3772-3773 [PUBMED].
Schaefer, K.N., Bonello, T.T., Zhang, S., Williams, C.E., Roberts, D.M., McKay, D.J, and Peifer, M. (2018). Supramolecular assembly of the beta-catenin destruction complex and the effect of Wnt signaling on its localization, molecular size, and activity in vivo. PLoS Genetics doi.org/10.1371/journal.pgen.1007339. [PUBMED] [Pre-revision biorxiv version]
Fadero, T.C., Gerbich, T.M. , Rana, K., Suzuki, A. DiSalvo, M., Schaefer, K.N., Heppert, J.K., Boothby, T.C, Goldstein, B., Peifer, M., Allbritton, N.L., Gladfelter, A.S., Maddox, A.S. and Maddox, P.S. (2018). LITE microscopy: Tilted light sheet excitation of model organisms offers high resolution and low photobleaching. Journal of Cell Biology doi: 10.1083/jcb.201710087, in press. [PUBMED] [Pre-revision biorxiv version]
Bonello, T.T., Perez-Vale, K.Z., Sumigray, K.D., and Peifer, M. (2018) Rap1 acts via multiple mechanisms to position Canoe/Afadin and adherens junctions and mediate apical-basal polarity establishment. Development doi: 10.1242/dev.157941, in press. [PUBMED] [Journal link] [Pre-revision biorxiv version]
2017
Peifer, M. (2017). The argument for diversifying the NIH grant portfolio. Molecular Biology of the Cell 28, 2935-2940. [PUBMED] [“preprint link“]
Peifer, M. (2017). Call to restore NIH’s cap on grant funding. [Letter to Editor]. Science, 357, 364. [“preprint link“]
Gladfelter, A.S., and Peifer M. (2017). What your PI forgot to tell you: why you actually might want a job running a research lab. Molecular Biology of the Cell, 28, 1724-1727 [PUBMED].
Poulton, J.S., Cuningham, J.C., and Peifer, M. (2017). Centrosome and Spindle Assembly Checkpoint Loss Leads to Neural Apoptosis and Reduced Brain Size. Journal of Cell Biology 216, 1255-1265. [PUBMED]
Pronobis, M.I., Deuitch, N., Posham, V., Mimori-Kiyosue, Y. and Peifer, M. (2017). Reconstituting regulation of the canonical Wnt pathway by engineering a minimal βcatenin destruction machine. Molecular Biology of the Cell 28, 41-53. [PUBMED]
2016
Pronobis, M.I., Deuitch, N., and Peifer, M. (2016). The Miraprep: A protocol that uses a Miniprep kit and provides Maxiprep yields. PLoS One 11, e0160509. [PUBMED]
Rogers, E.M., Spracklen, A.J., Bilancia, C.G., Sumigray, K.D., Allred, S.C., Nowotarski, S.N., Schaefer, K. N., Ritchie, B.J., and Peifer, M. (2016). Abelson kinase acts as a robust, multifunctional scaffold in regulating embryonic morphogenesis. Molecular Biology of the Cell 27, 2613-2631. [PUBMED]
Choi, W., Acharya, B.R., Peyret, G., Fardin, M-A. Mège, R-M., Ladoux, B., Yap, A.S., Fanning, A.S., Peifer, M. (2016). Remodeling the zonula adherens in response to tension and the role of afadin in this response. Journal of Cell Biology 213, 243-260. [PUBMED]
2015
Spracklen, A.J., and Peifer, M. (2015). Actin and Apical Constriction: Some (Re)-Assembly Required. Developmental Cell 35, 662-4. [PubMed]
Pronobis, M.I., Rusan, N.M., and Peifer, M. (2015). A novel GSK3-regulated APC:Axin interaction regulates Wnt signaling by driving a catalytic cycle of efficient βcatenin destruction. eLife 4, e08022. [PubMed]
Lerit, D.A., Jordan, H.A., Poulton, J.S., Fagerstrom, C.J., Galletta, B.J., Peifer, M., and Rusan, N.M. (2015). Interphase centrosome organization by the PLP-Cnn scaffold is required for centrosome function. Journal of Cell Biology 210, 79-97. [PubMed]
2014
Poulton, J.S., Cuningham, J.C., and Peifer, M. (2014). Acentrosomal Drosophila epithelial cells exhibit abnormal cell division, leading to cell death and compensatory proliferation. Developmental Cell 30, 731-745. [MEDLINE]
Nowotarski, S.H., McKeon, N., Moser, R.J., and Peifer, M. (2014). The actin regulators Enabled and Diaphanous direct distinct protrusive behaviors in different tissues during Drosophila development. Molecular Biology of the Cell 25, 3147-65. [MEDLINE]
Nowotarski, S.H., and Peifer, M. (2014). Cell Biology: A tense but good day for actin at cell-cell junctions. Current Biology 24, R688-90. [MEDLINE}
Winkelman, J.D., Bilancia, C.G. Peifer, M., and Kovar, D.R.. 2014 . Ena/VASP Enabled is a highly processive actin polymerase tailored to self-assemble parallel-bundled F-actin networks with Fascin. Proceedings of the National Academy of Science USA 111, 4121-6. [MEDLINE]
Bilancia, C.G. ,Winkelman, J.D., Tsygankov, D., Nowotarski, S.H. , Sees, J.A., Comber, K., Evans, I., Lakhani, V., Wood, W., Elston, T.C., Kovar, D. R., and Peifer, M. 2014 . Enabled negatively regulates Diaphanous-driven actin dynamics in vitro and in vivo. Developmental Cell 28, 394-408. [MEDLINE]
Tsygankov, D., Bilancia, C.G., Vitriol, E.A., Hahn, K.M,, Peifer, M.*, Elston, T.C.* (*=co-corresponding). CellGeo: a Computational Platform for the Analysis of Shape Changes in Cells with Complex Geometries. Journal of Cell Biology 204, 443-460. [MEDLINE]
2013
Manning, A.J., Peters, K.A., Peifer, M.*, and Rogers, S.L.* (*=co-corresponding). (2013) Regulation of Epithelial Morphogenesis by the G-Protein Coupled Receptor Mist and its Ligand Fog. Science Signaling 6, ra98. [MEDLINE]
Poulton, J.S., Mu, F.W., Roberts, D.M., and Peifer, M. (2013). APC2 and Axin promote mitotic fidelity by facilitating centrosome separation and cytoskeletal regulation. Development 140, 4226-4236. [MEDLINE]
Ellis, S.J., Goult, B.T.,, Fairchild, M.J.,, Harris, N.J., Long, J., Lobo, P., Czerniecki, S., Van Petegem, F., Schöck, F., Peifer,M., Tanentzapf, G. (2013) Talin autoinhibition is required for morphogenesis. Current Biology 23(18):1825-33 [MEDLINE]
Choi, W., Harris, N. J., Sumigray, K.D., and Peifer, M. (2013). Rap1 and Canoe/afadin are essential for establishment of apical-basal polarity in the Drosophila embryo. Molecular Biology of the Cell 24, 945-963. [MEDLINE]
2012
Gao, L., Shao, L., Higgins, C.D., Poulton, J.S., Peifer, M., Davidson, M.W., Wu, X., Goldstein, B., and Betzig, E. Noninvasive Imaging of Three-Dimensional Dynamics in Thickly Fluorescent Specimens Beyond the Diffraction Limit. Cell 151, 1370-1385. [MEDLINE]
Sumigray, K.D. and Peifer, M. (2012) Cell shape by coercion: Par1 and aPKC put the squeeze on junctions. Developmental Cell 22, 907-908 [MEDLINE].
Roberts,D.M., Pronobis, M.I., Poulton, J.S., Kane, E.G., and Peifer, M. (2012) Regulation of Wnt signaling by the tumor suppressor APC does not require ability to enter the nucleus nor a particular cytoplasmic localization. Molecular Biology of the Cell 23, 2041-2056. [MEDLINE]
Pronobis, M.I., and Peifer, M. (2012) Wnt signaling: The many interfaces of ß-catenin. Current Biology 22, R137-139 [MEDLINE].
Roberts,D.M., Pronobis, M.I., Alexandre, K.M., Rogers, G.C., Schneider, D.E., Jung, K-C., Poulton, J.S., McKay, D. J., ., and Peifer, M. (2012) Defining components of the ßcatenin destruction complex and exploring its regulation and mechanisms of action during development. PLoS One 7: e31284. [MEDLINE]
2011
Choi, W. and Peifer, M. (2011). Arranging a Cellular Checkerboard. Science 333, 1099-110. [MEDLINE]
Sawyer, J.K., Choi, W., Jung, K.-C., Hi, L., Harris, N.J., =and Peifer, M. (2011). A contractile actomyosin network linked to adherens junctions by Canoe/afadin helps drive convergent extension. Molecular Biology of the Cell 22, 2491-2508. [MEDLINE]
Choi, W., Jung, K.-C., Nelson, K.S., Bhat, M.A., Beitel, G.J.,Peifer, M., and Fanning, A.S. (2011). The single Drosophila ZO-1 protein Polychaetoid regulates embryonic morphogenesis in coordination with Canoe/Afadin and Enabled. Molecular Biology of the Cell 22, 2010-2030. [MEDLINE]
Roberts, D.M., Pronobis, M.I., Poulton, J.S., Waldmann, J.D., Stephenson, E.M., Hanna, S., and Peifer, M. (2011). Deconstructing the ßcatenin destruction complex: mechanistic roles for the tumor suppressor APC in regulating Wnt signaling. Molecular Biology of the Cell 22, 1845-1863. [MEDLINE]
2009
Homem, C.C.F., and Peifer, M. (2009). Exploring the roles of Diaphanous and Enabled activity in shaping the balance between filopodia and lamellipodia. Molecular Biology of the Cell 20, 5138-55. [MEDLINE]
Sawyer, J.K, Harris, N. J, and Peifer, M. (2009) Morphogenesis: Multitalented GTPases seeking new jobs. Current Biology 19, R985-R987. [MEDLINE]
Roeth, J.F., Sawyer, J.K., Wilner, D.A., and Peifer, M. (2009). Rab11 Helps Maintain Apical Crumbs and Adherens Junctions in the Drosophila Embryonic Ectoderm. PLoS One 4, e7634. [MEDLINE]
Gates, J., ,Nowotarski,S.H., Yin, H., Mahaffey, J.P., Bridges, T., Herrera,C., Homem,C.C.F., Janody, F., Montell, D.J.and Peifer,M. (2009) Enabled and Capping protein play important roles in shaping cell behavior during Drosophila oogenesis. Developmental Biology 333, 90-107. [MEDLINE]
Sawyer, J.K., Harris, N.J., Slep, K.C., Gaul, U., and Peifer, M. (2009) The Drosophila afadin homolog Canoe regulates linkage of the actin cytoskeleton
to adherens junctions during apical constriction. Journal of Cell Biology 186, 57-73.[MEDLINE]
Cadigan, K.M., and Peifer, M. (2009) Wnt Signaling from Development to Disease: Insights from Model Systems. Cold Spring Harb Perspect Biol 1, a002881 doi: 10.1101/cshperspect.a002881 [MEDLINE]
Rogers,G.C., Rusan, N.M., Roberts,D.M., Peifer, M., and Rogers, S.L. (2009) The SCFSlimb ubiquitin-ligase regulates Plk4/Sak levels to block centriole reduplication. Journal of Cell Biology 184, 225-239. [MEDLINE]
Harris, T.J.C., Sawyer, J.K., and Peifer, M. (2009). How the cytoskeleton helps build the embryonic body plan: Models of morphogenesis from Drosophila. Current Topics in Developmental Biology 89, 55-85. [MEDLINE]
2008
Duncan, M.C., and Peifer, M. (2008). Regulating polarity by directing traffic: Cdc42 prevents adherens junctions from Crumblin’ aPart. Journal of Cell Biology 183: 971-974. [MEDLINE]
Rusan, N.M., Akong, K., and Peifer, M. (2008). Putting the model to the test: are APC proteins essential for neuronal polarity, axon outgrowth
and axon targeting?. Journal of Cell Biology 183, 203-212. [MEDLINE]
Rusan, N.M., and Peifer, M. (2008). Original CIN: reviewing roles for APC in chromosome instability. Journal of Cell Biology181,719-726.[MEDLINE]
Rogers, G.C., Rusan, N.M., Peifer, M.and Rogers, S.L. (2008). A Multi-Component Assembly Pathway Contributes to the Formation of Acentrosomal Microtubule Arrays in Interphase Drosophila cells. Molecular Biology of the Cell 19:3163-78. [MEDLINE]
Gottardi, C.J., and Peifer, M. (2008). Terminal regions of ß-catenin come into view. Structure 16, 336-338. [MEDLINE]
Homem, C.C.F., and Peifer, M. (2008) Diaphanous regulates myosin and adherens junctions to control
cell contractility and protrusive behavior during morphogenesis. Development 135, 1005-1018. [MEDLINE]
Stevens, T L., Rogers, E M., Koontz, L. M. , Fox, D. T., Homem, C. C.F., Nowotarski, S. H., Artabazon, N. B., and Peifer, M. (2008). Using Bcr-Abl to examine mechanisms by which Abl kinase regulates morphogenesis in Drosophila. Molecular Biology of the Cell 19, 378-393. [MEDLINE]
2007
Roberts, D.M., Slep, K.C., and Peifer, M. (2007). It takes more than two to tango: Dishevelled polymerization and Wnt signaling. Nature Structural and Molecular Biology 14, 463-465. [MEDLINE]
Gates, J., Mahaffey, J.P., Rogers, S.L., Emerson, M., Rogers, E.M., Sottile, S.L., Van Vactor, D., Gertler, F.B., and Peifer, M. (2007). Enabled plays key roles in Embryonic Epithelial Morphogenesis in Drosophila. Development 134, 2027-2039. [MEDLINE]
Harris, T.J.C., and Peifer, M. (2007). aPKC controls microtubule organization to balance adherens junction symmetry and planar polarity during development. Developmental Cell 12, 727-738.[MEDLINE]
Rusan, N.M., and Peifer, M. (2007). A role for a novel centrosome cycle in asymmetric cell division. Journal of Cell Biology 177, 13-20.[MEDLINE]
Hayden, M.A., Akong, K., and Peifer, M. (2007). Novel roles for APC family members and Wingless/Wnt signaling during Drosophila brain development. Developmental Biology 305, 358-376. [MEDLINE]
Fox, D.T., and Peifer, M. (2007). Abelson kinase and RhoGEF2 regulate actin organization during cell constriction in Drosophila. Development 143, 567-578. [MEDLINE]
Fox, D.T., and Peifer, M. (2007). Cell adhesion: Separation of p120’s powers? Current Biology 17, R24-R27.[MEDLINE]
2006
McCartney, B.M., Price, M.H., Webb, R., , Hayden, M.A., Holot, L., Zhou, M, Bejsovec, A., and Peifer, M. (2006). Testing hypotheses for the functions of APC family proteins using null and truncation alleles in Drosophila. Development 133, 2407-2418. [MEDLINE]
Price, M.H., Roberts, D.M., McCartney, B.M., Jezuit, E., and Peifer, M. (2006). Cytoskeletal dynamics and cell signaling during planar polarity establishment in the Drosophila embryonic denticle. Journal of Cell Science 119: 403-415. [MEDLINE]
2005
Gates, J., and Peifer, M. (2005). Can 1000 reviews be wrong? Actin, alpha-catenin and adherens junctions. Cell 123, 769-772. [MEDLINE]
Fox, D.T., Homem, C.C.F., Myster, S.H., Wang, F., Bain, E.E., and Peifer, M. (2005). Rho1 Regulates Drosophila Adherens Junctions Independently of p120ctn. Development 132, 4819-4831. [MEDLINE]
Harris, T.J.C., and Peifer, M. (2005). The positioning and segregation of apical cues during epithelial polarity establishment in Drosophila. Journal of Cell Biology 170, 813-823. [MEDLINE]
McEwen,D.G., and Peifer, M. (2005). Puckered, a Drosophila MAPK phosphatase, ensures cell viability by antagonizing JNK-induced apoptosis. Development 132, 3935-3946. [MEDLINE]
2004
Harris, T.J.C., and Peifer, M. (2004). Decisions, decisions: beta-catenin chooses between adhesion and transcription. Trends in Cell Biology15, 2345-237. [MEDLINE]
Harris, T.J.C., and Peifer, M. (2004). Adherens junction-dependent and -independent steps in the establishment of epithelial cell polarity in Drosophila. Journal of Cell Biology165, 135-147. [MEDLINE]
2003
Grevengoed, E.E., Fox, D.T., Gates, J., and Peifer, M. (2003). Balancing different types of actin polymerization at distinct sites: Roles for Abelson kinase and Enabled. Journal of Cell Biology 163, 1267-1280. [MEDLINE]
McCartney, B.M., and Peifer, M. (2003). Stem Cells in the News: CNN and APC Make Headlines. Developmental Cell 5, 532-4.[MEDLINE ]
Myster, S.H., Cavallo, R., Anderson, C.T., Fox, D.T., and Peifer, M. (2003). Drosophila p120catenin plays a supporting role in cell adhesion but is not an essential adherens junction component. The Journal of Cell Biology 160, 433-449. [ MEDLINE ]
2002
Peifer, M. (2002). Developmental Biology: Colon construction. Nature 420, 274-276.
Peifer, M., and McEwen, D.G. (2002). The ballet of morphogenesis: unveiling the hidden choreographers. Cell 109, 271-274. [MEDLINE]
Akong, K. McCartney., B.M., and Peifer, M. (2002). Drosophila APC1 and APC2 have overlapping roles in the larval brain despite their distinct intracellular localizations. Developmental Biology 250, 71-90. [MEDLINE ]
Akong, K., Grevengoed, E.E., Price, M.H., McCartney., B.M., Hayden, M.A., DeNofrio, J.C. and Peifer, M. (2002). Drosophila APC1 and APC2 playoverlapping roles in Wingless signaling in the embryo and imaginal discs. Developmental Biology 250, 91-100. [MEDLINE ]
2001
Grevengoed, E.E., Loureiro, J.J., Jesse, T.L., and Peifer M. (2001). Abelson kinase regulates epithelial morphogenesis in Drosophila. Journal of Cell Biology , 155, 1185-1197. [MEDLINE ]
McCartney, B.M., McEwen, D.G., Grevengoed, E., Maddox, P., Bejsovec, A., Peifer, M. (2001). Drosophila APC2 and Armadillo participate in tethering mitotic spindles to cortical actin. Nature Cell Biology 3, 933-938. [MEDLINE ]
Simcha, I., Kirkpatrick, C., Sadot, E., Shtutman, M. Polevoy, G., Geiger, B., Peifer, M., and Ben-Ze’ev, A. (2001). Cadherin Sequences that Inhibit ß-catenin Signaling: a Study in Yeast and Mammalian Cells. Molecular Biology of the Cell 12: 1177-88.[MEDLINE ]
2000
Tepass, U., Truong, K., Godt, D., Ikura, M., Peifer, M. (2000). Cadherins in embryonic and neural morphogenesis. Nature Reviews: Molecular Cell Biology1: 91-100.[MEDLINE]
Adam, J.C., Pringle, J.R., and Peifer, M. (2000). Evidence for functional differentiation among Drosophila septins in cytokinesis and cellularization.Molecular Biology of the Cell 11: 3123-3135. [MEDLINE]
Peifer, M. (2000). Travel bulletin: traffic jams cause tumors. Science 289: 67-69.
McEwen, D.G., Cox, R.T., and Peifer, M. (2000). The canonical Wg and JNK signaling cascades collaborate to promote both dorsal closure and ventral patterning. Development 127: 3607-3617. [ MEDLINE ]
Cox, R.T., McEwen, D.G., Myster, D.G., Duronio, R.J., Loureiro, J., and Peifer, M. (2000). A screen for mutations that suppress the phenotype ofDrosophila armadillo, the b-catenin homolog. Genetics 155: 1725-1740. [MEDLINE]
McCartney, B.M., and Peifer, M. (2000). Teaching tumor suppressors new tricks. Nature Cell Biol. 2: E58-60.
Peifer, M., and Polakis, P. (2000). Wnt signaling in oncogenesis and embryogenesis: A look outside the nucleus. Science 287: 1606-1609. [MEDLINE ]
Peifer, M., and Tepass, U. (2000). Cell Biology: Which way is up? Nature 403: 611-612.
1999
McCartney, B., Dierick, H.A., Kirkpatrick, C., Moline, M.M., Baas, A., Peifer, M., and Bejsovec, A. (1999) Drosophila APC2 is a cytoskeletally-associated protein that regulates Wingless signaling in the embryonic epidermis. Journal of Cell Biology 146: 1303-1318. [MEDLINE ]
Peifer, M. (1999). Signal transduction: Neither straight nor narrow. Nature 400: 213-215.
Cox, R.T., Pai, L.-M., Kirkpatrick, C., Stein, J., and Peifer, M. (1999). Roles of the C-terminus of Armadillo in Wingless signaling in Drosophila. Genetics153: 319-332. [MEDLINE ]
Cox, R.T., Pai, L.-M., Miller, J.R., Orsulic, S., Stein, J., McCormick, C.A., Audeh, Y., Wang, W., Moon, R.T., and Peifer, M. (1999). Membrane-tethered Drosophila Armadillo cannot transduce Wingless signal on its own. Development 126: 1327-1335. [MEDLINE ]
Lu, Q., Paredes, M., Medina, M., Zhou, J., Cavallo, R., Peifer, M., Orecchio, L. and Kosik, K.S. (1999). Delta-catenin, an adhesive junction-associated protein which promotes cell scattering. J. Cell Biol. 144: 519-532.
van Es, J.H., Kirkpatrick, C., van de Wetering, M., Molenaar, M., Miles, A., Kuipers, J., Destree, O., Peifer, M., and Clevers, H. (1999). Identification of APC2, a homologue of the adenomatous polyposis coli tumour suppressor. Current Biology 9: 105-108. [ MEDLINE ]
1998
Cavallo, R.A., Cox, R.T., Moline, M.M., Roose, J., Polevoy, G.A., Clevers, H., Peifer, M., and Bejsovec, A. (1998). Drosophila TCF and Groucho interact to repress Wingless signaling activity. Nature 395: 604-608. [MEDLINE ]
Loureiro, J., and Peifer, M. (1998). The roles of Armadillo, a Drosophila catenin, during central nervous system development. Current Biology 8: 622-632.[MEDLINE ]
1997
Pai, L.-M., Orsulic, S., Bejsovec, A. and Peifer, M. (1997). Negative regulation of Armadillo, a Wingless effector in Drosophila. Development 124: 2255-2266. [MEDLINE ]
van de Wetering, M., Cavallo, R., Dooijes, D., van Beest, M., van Es, J., Loureiro, J., Ypma, A., Hursh, D., Jones, T., Bejsovec, A., Peifer, M., Mortin, M., and Clevers, H. (1997). Armadillo co-activates transcription driven by the product of the Drosophila segment polarity gene dTCF. Cell 88: 789-799.[MEDLINE]
Peifer, M. (1997). ß-catenin as oncogene–the smoking gun. Science 275: 1752-1753. [FULL TEXT ]
1996
Orsulic, S., and Peifer, M. (1996). An in vivo structure-function study of Armadillo, the ß-catenin homolog, reveals both separate and overlapping regions of the protein required for cell adhesion and for Wingless signaling. J. Cell Biol. 134: 1283-1301. [MEDLINE]
Cox, R., Kirkpatrick, C., and Peifer, M. (1996). Armadillo is required for adherens junction assembly, cell polarity and morphogenesis during Drosophilaembryogenesis. J. Cell Biol. 134: 133-148. [ MEDLINE ]
Pai, L.-M., Kirkpatrick, C., Blanton, J., Oda, H., Takeichi, M., and Peifer, M. (1996). a-catenin and DE-cadherin occupy distinct binding sites onDrosophila Armadillo that differ substantially in size. J. Biol. Chem. 271: 32411-32420. [MEDLINE ]
1995
Fares, H., Peifer, M., and Pringle, J.P. (1995). Localization and possible functions of Drosophila septins. Mol. Biol. Cell 6: 1843-1859. [MEDLINE ]
Peifer, M. (1995) Cell adhesion and signal transduction–the Armadillo connection (review). Trends Cell Bio. 5: 224-229.
Kirkpatrick, C., and Peifer, M. (1995) Not just glue- cell-cell junctions as cellular signaling centers (review). Curr. Opin. Genet. Devel. 5: 56-65.
Rauskolb, C., Smith, K., Peifer, M., and Wieschaus, E. (1995) extradenticle determines segmental throughout Drosophila development. Development 121: 3663-3673.
1994
Peifer, M., Pai, L.-M., and Casey, M. (1994). Phosphorylation of the Drosophila adhesive junction protein Armadillo: roles for Wingless signal and Zeste white-3 kinase. Dev. Biol. 166: 543-556.
Peifer, M., Sweeton, D., Casey, M., and Wieschaus, E. (1994) wingless signal and Zeste-white 3 kinase trigger opposing changes in the intracellular distribution of Armadillo. Development 120: 369-380.
