Research Information

My work currently involves using biochemistry, molecular biology, and structural techniques to develop a better understanding of the structure and function of Canoe, the Drosophila homolog of mammalian Afadin.  Canoe plays a key role in embryonic morphogenesis, helping link cell-cell adhesive junctions to the actomyosin cytoskeleton. I am working to determine how the domains that constitute Canoe interact with each other, as well as with other proteins involved in cell-cell adhesion such as Rap1.