Amber Butcher

 

Background & Contact Information

Position Postbac researcher (2021 – Present)
Education: BS Biology, UNC Chapel Hill (2021)
Email: tifamber@live.unc.edu

 

Research Information

My work currently involves using biochemistry, molecular biology, and structural techniques to develop a better understanding of the structure and function of Canoe, the Drosophila homolog of mammalian Afadin.  Canoe plays a key role in embryonic morphogenesis, helping link cell-cell adhesive junctions to the actomyosin cytoskeleton. I am working to determine how the domains that constitute Canoe interact with each other, as well as with other proteins involved in cell-cell adhesion such as Rap1.

Publications

McParland, E.D.*, Butcher, T.A.*, Gurley, N.J., Johnson, R.I., Slep, K.C., and Peifer, M. (2024) Canoe’s Dilute domain is not essential for linking cell junctions to the cytoskeleton but supports morphogenesis robustness. Journal of Cell Science, in press. *=co-first authors.

Gurley, N.J., Szymanski, R.A., Dowen, R.H., Butcher, T.A., Ishiyama, N. and Peifer, M.  (2023).  Exploring the evolution and function of Canoe’s intrinsically disordered region in linking cell-cell junctions to the cytoskeleton during embryonic morphogenesis.  PLoS One 18: e0289224.

 

Comments are closed.

Copyright 2024 Peifer Lab · RSS Feed · Log in

Site By: Ruby Red Design Studio

Mark Peifer Mark Peifer