MORPHOGENESIS
We use developing embryos to explore the cell biology of morphogenesis—in this gastrulating embryo cytoskeletal (blue) and adhesion proteins (red) become reciprocally planar polarized.
CELL CULTURES
We also use cultured Drosophila and mammalian cells to explore adhesion and Wnt signaling. This D17 cell illustrates how we can examine protrusive behavior in vitro.
IN 3D
Our image analysis software allows us to explore protein localization in 3D. Here nuclei (green) collide during mitosis due to failure of the tumor suppressor APC to regulate centrosome (red) and cytoskeletal (blue) dynamics.
POLARIZATION
Drosophila embryos provide a superb place to assess the mechanisms by which cells polarize. This cellularizing embryo has basal actin rings (green) with basal junctions (red) just apical to them.
